Susceptibility of Ferrets (Mustela putorius furo) to Experimentally Induced Rabies with European Bat Lyssaviruses (EBLV)
Identifieur interne : 000592 ( Istex/Checkpoint ); précédent : 000591; suivant : 000593Susceptibility of Ferrets (Mustela putorius furo) to Experimentally Induced Rabies with European Bat Lyssaviruses (EBLV)
Auteurs : A. Vos [Allemagne] ; T. Müller [Allemagne] ; J. Cox [Allemagne] ; L. Neubert [Allemagne] ; A. R. Fooks [Royaume-Uni]Source :
- Journal of Veterinary Medicine, Series B [ 0931-1793 ] ; 2004-03.
Abstract
Twenty ferrets (Mustela putorius furo) were inoculated by intramuscular (i.m.) injection with European Bat Lyssaviruses (EBLV) type‐1 and 2 using 104.0 foci‐forming units (FFU) EBLV‐2 (n = 6), 104.0 FFU EBLV‐1 (n = 7) and 106.0 FFU EBLV‐1 (n = 7). Furthermore, 15 mice received 102.5 FFU EBLV‐2 (n = 5), 102.5 FFU EBLV‐1 (n = 5) and 104.5 FFU EBLV‐1 (n = 5) by i.m. inoculation. All ferrets and mice receiving the higher dose of EBLV‐1 succumbed to infection. In contrast, only three of seven ferrets and two of five mice inoculated experimentally with the lower EBLV‐1 dose died. By comparison, all of the EBLV‐2 infected ferrets and four of five mice survived infection. All 20 infected ferrets seroconverted. Using sensitive molecular tools, the virus was detected in different tissues, but it could not be found in any saliva samples taken during the 84‐day observation period.
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DOI: 10.1111/j.1439-0450.2004.00730.x
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Cox</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>WHO Collaborating Centre for Rabies Research and Surveillance, Federal Research Centre for Virus Diseases of Animals, PO Box 1149, 72001 Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Stuttgart</region><settlement type="city">Stuttgart</settlement></placeName></affiliation></author><author><name sortKey="Neubert, L" sort="Neubert, L" uniqKey="Neubert L" first="L." last="Neubert">L. Neubert</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Addresses of authors: IDT GmbH, PO Box 214, 06855 Rosslau</wicri:regionArea><wicri:noRegion>06855 Rosslau</wicri:noRegion><wicri:noRegion>06855 Rosslau</wicri:noRegion></affiliation></author><author><name sortKey="Fooks, A R" sort="Fooks, A R" uniqKey="Fooks A" first="A. R." last="Fooks">A. R. Fooks</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Rabies Research and Diagnostics Group, (WHO Collaborating Centre for the Characterisation of Rabies and Rabies‐Related Viruses), Veterinary Laboratories Agency – Weybridge, New Haw, Addlestone, Surrey KT15 3NB</wicri:regionArea><wicri:noRegion>Surrey KT15 3NB</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Veterinary Medicine, Series B</title><idno type="ISSN">0931-1793</idno><idno type="eISSN">1439-0450</idno><imprint><publisher>Blackwell Verlag GmbH</publisher><pubPlace>Berlin, Germany</pubPlace><date type="published" when="2004-03">2004-03</date><biblScope unit="volume">51</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="55">55</biblScope><biblScope unit="page" to="60">60</biblScope></imprint><idno type="ISSN">0931-1793</idno></series><idno type="istex">08CC0D94504A35AFE22470BCAB1E38A5EA64443F</idno><idno type="DOI">10.1111/j.1439-0450.2004.00730.x</idno><idno type="ArticleID">ZPH730</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0931-1793</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Twenty ferrets (Mustela putorius furo) were inoculated by intramuscular (i.m.) injection with European Bat Lyssaviruses (EBLV) type‐1 and 2 using 104.0 foci‐forming units (FFU) EBLV‐2 (n = 6), 104.0 FFU EBLV‐1 (n = 7) and 106.0 FFU EBLV‐1 (n = 7). Furthermore, 15 mice received 102.5 FFU EBLV‐2 (n = 5), 102.5 FFU EBLV‐1 (n = 5) and 104.5 FFU EBLV‐1 (n = 5) by i.m. inoculation. All ferrets and mice receiving the higher dose of EBLV‐1 succumbed to infection. In contrast, only three of seven ferrets and two of five mice inoculated experimentally with the lower EBLV‐1 dose died. By comparison, all of the EBLV‐2 infected ferrets and four of five mice survived infection. All 20 infected ferrets seroconverted. Using sensitive molecular tools, the virus was detected in different tissues, but it could not be found in any saliva samples taken during the 84‐day observation period.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li></country><region><li>Bade-Wurtemberg</li><li>District de Stuttgart</li></region><settlement><li>Stuttgart</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Vos, A" sort="Vos, A" uniqKey="Vos A" first="A." last="Vos">A. Vos</name></noRegion><name sortKey="Cox, J" sort="Cox, J" uniqKey="Cox J" first="J." last="Cox">J. Cox</name><name sortKey="Muller, T" sort="Muller, T" uniqKey="Muller T" first="T." last="Müller">T. Müller</name><name sortKey="Neubert, L" sort="Neubert, L" uniqKey="Neubert L" first="L." last="Neubert">L. Neubert</name><name sortKey="Vos, A" sort="Vos, A" uniqKey="Vos A" first="A." last="Vos">A. Vos</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Fooks, A R" sort="Fooks, A R" uniqKey="Fooks A" first="A. R." last="Fooks">A. R. Fooks</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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